Thursday 31 October 2013

Ayurvedic Research Views -- By Prof.Dr.R.R.Deshpande on 31-10-13

About Ayurvedic Research –
By Prof.Dr.R.R.Deshpande
Uploaded on 31-10-13

Teachers Should not be forced to undertake Research Activity of his own
Recently ,I have attended one day workshop on Scientific writing for Research on 22 Oct 13 .Also I am hearing that MUHS is making compulsion on teachers to undertake Research Activities & publish their Research Papers in peer review Journals .Otherwise Teachers will not be eligible for BOS ,Academic boards,Examinership etc etc .During discussion with Teachers & Masters in Research Activities ,I am getting different impressions from different people .
Research masters that means Teachers ,who are fond of Research ,strong liking for Research ,they try to learn about Research Actvities,Scientific writing,publish their papers .These people then become masters of Research ,as compare to Normal Teachers ,who are mainly interested in Self Learning,Teaching,guiding students for better success,doing University work like taking Exams,paper checking,syllabus forming,writing books for students & lay people ,Clinical Teachers are all time engaged in examing & treating patients successfully,keeping record of patients in the hospitals neately,All teachers are also organizing various seminars ,Guest Lectures,Maintaining Dead stock of depts.,Maintenance & new purchase of Instruments,models,charts,Facing different visits of CCIM,AYUSH,MUHS etc,nearly intermittently but for the whole year. Also now in these recent years many teachers are guiding Post Graduate students in their research work,taking PG lectures & discussing various topics of the syllabus .Teachers are doing all these things as per their duties & Interest .In addition those who are interested & time ,they are undertaking small Research projects .This is all ok .
But the problem starts ,when Each Teacher is asked to undertake Research or publish ,without his own interest & mainly without considering Time restraint ,that the Teacher has .
Another problem ,which is more serious that Research Masters ( Research minded Teachers) feel that they are only survivors of Ayurveda .They feel & talk that without Research ,Ayurveda can not progress nevertheless Boat of Ayurveda will sink ,if Ayurvedic college Teachers ,will not do Research or Publish their Research papers.How egoistic this opinion is ?? These thoughts totally wrong .One of the expert says that see ,whether without Petrol can car move ? So research is like petrol .This statement is totally wrong .To drive a car there are so many things are required like Engine in good condition,Accelerator,Breaks,Handle & mainly good driver .In short what I want to say is that ,it is OK ,that Research is one of the important factor in Ayurveda progress & sustenance ,but Research is NOT ONLY THE THING.
We must try to look this matter of Ayurveda progress in a holistic manner.
1) We must try to get Rajashraya or Govertment support to Ayurveda.Ayurveda should get a place in National Health Policies 2) From School level Ayurveda should be introduced to children .Like we have chapters on Invention of Pencillin ,TB bacteria ,Vitamin deficiency diseases,Proteins,Carbohydrates etc .But school going children & even adults do not know about Charak,Sushruta,Ayurvedic Rules of eating,concept of Vata,Pitta & Kapha.
3) Haphazard Research topics of MD students.There is no Data Base of Ayurvedic past researches for Review ( I would like to mention that myself ,Prof.Dr.R.R.Deshpande first time introduced his brain child to MUHS of Ayurvedic Research Data Base (ARDB) .With 1  lakh funding Ayurveda college ,Nigdi ,completed it’s first phase .Data base is or was available on web site – www.ayurvedresearch.in .) But unfortunately then this work got stuck up due to technical reason.If there previous Data Base is not available ,there will be duplication of work & wastage of Time,Money & Energy.
4) In spite of haphazard research ,retrospective Research will be more useful .Successful stories should be collected from renowned practioners & their success stories can be converted into Scientific mode by undertaking Research on their experiences.
5) For Progress of Ayurveda – Teachers,Practioners,Consulting Physicians,Researchers,Stake holders,Technical experts all are needed & everybody is important .So there must be Team work for the progress of science.
6) We must also understand ,even without any Research & scientific paper writing in the fashion that we are enforcing today ,Ayurveda is existing from time Immortal   ( Please do not give me example of Scientific conferences held at the base of Himalaya etc – that everybody knows about research attitude at Samhita period – that can be compared with Teachers discussions amongst themselves or Teacher’s discussion with students ) .Ayurveda is existing & will exist because of it’s – Fundamental principles,Successful treatments,Ayurvea literature Scientific as well as Popular Literature,Ayurveda propogation in Europe,Post graduation Research studies.
7) Post Graduate students have full time Job to think & do Research Activities .Ayurvedic Teachers,yes ,can do something in Research with these Post Graduate students just by guiding them,but not as a separate responsibility
8) We must understand that Research is a full time Activity .Research Activities comes through Curiosity,Clinical Experinences,Doubts & some time as a accidental finding also.
9) Also note that Researcher,Teacher,Practioner,writer everybody has different set of mind ,different life goals,different Life frame work .This is similar to Ayurvedic Prakruti or Biotype concept .Ayurvedic people also can be classified as Teacher Prakruti,Researcher Prakruti,Physician Prakruti,Writer prakruti etc.Physical & Mental Health can be maintained ,if everybody keeps his or her life style as per our prakruti,mentioned as above.
10) How Team work will be more beneficial ,with concern to Research ? – For example in Pune ,when Dr.Jagdish Hiremath ,well-known cardiologist,is doing research Activity ,he has a Team of people of Clinical Research .He just continue his expertise in examining & treating Heart patients & provides his data of observations to his Team to analyse & conclude & guide them for publishing it .Similarly Ayurvedic Physicians will do their job of examination & treating patients .Then group of Research worker ,Technical person make hand in hand with these physicians ,collect data,analyse it,draw conclusions & publish it ,mentioning name of Physician
.11) Tragedy in the sector of Ayurvedic Research – There are National Institutes like CCRAS OR ICMR .They have Team of people ,employed for only doing research as a full time job with good salary .But do we really think that Common Medical Practioner or Ayurveda Teachers or Ayurveda Students from nook & corner of India are getting benefitted by Researches done in these Institutes ?? Whether we get Medicines coming out of Research at the Medical shop near to my clinic ? Whether all publications of CCRAS or ICMR are available at my near Medical Book store ?? Why this can not happen ?? So is this not a big gap in Research Activity & it’s benefit to Ayurved community ??
12) Similarly another Big Gap – There are lot of Successful Ayurveda Vaidyas at nook & corner of India .But as these vaidyas are very busy in their practice & also not interested in ABC of Research – Successful treatments can not get published in Scientific Journals & get recognition Internationally & also can not be benefitted to other practioners,Teachers or students .
Supporting to my article ,I have shared also one PPT show of the same kind .Please enter this link & you will see it

To sum up ,Ayurvedic Research is one of the Good Activity for Scientific progress.But Research is NOT ONLY THE THING ,for Ayurved’s Progress.Ayurvedic College Teachers should not be forced to do Research Activities ( Another than as a Guide to PG student)
Please write me your feed back by commenting on this article,take print out of it ,give publicity to it at your place ,continue discussing contents of this article,mail me on mailme.drrrdeshpande@rediffmail.com or phone me – 922 68 10 630
Kindly note my personal web site – www.ayurvedicfriend.com is under renovation .Open again in couple of months
Thanks.Have a nice Life !! Prof.Dr.R.R.Deshpande


Tuesday 29 October 2013

Real meaning of Diwali or Deepavali by Prof.Dr.R.R.Deshpande on 30-10-13

Real Meaning of Diwali or Deepavali
Prof.Dr.R.R.Deshpande ( 922 68 10 630) ,
uploaded on 30-10-13

Deepavali is the Festival of Light,Festival of Brightness,Festival of Enthusiasm,Festival of Energy.This Festival is a Gathering of Joyful events of 3 or 4 days.

Narakchaturdashi,Laxmipujan,Padva ( Bala pratipada),Bhaubeeja – Each day explicit some cultural thought,cultural Philosophy

1)  Narakchaturdashi – It is also called as Kali Chaturdashi.Kali means power or strength ,utilized for demolishing Demon activities.King Narkasur became devil due to his extra strong physical power.He was nuisance to common man .He was doing sexual harassment of women.On this particular day of Diwali, this beast or animal  like Narkasur was killed by God Krishna.To celebrate this victory of Divine over Devil ,people lightened their houses,cities & roads.So begins Festival of Light.

2)  Laxmi Pujan --- Laxmi means Goddess of Wealth.Pujan means worship.This is the day to worship wealth .Indian culture explained 4 goals of Life as Dharma ( Righteous duties) ,Artha ( Acquiring wealth) ,Kama ( Enjoyment of Life) & Moksha ( Eternal Happiness) .Indian culture has never disregard the Importance of Wealth  or Laxmi.Laxmi is given respect as mother. Wealth is like Energy or Power. It should have base of Dharma or Righteous duties.By utilizing it positively ( for self, Family, Society, Charity) ,person can enjoy godly activities. Acquiring & using wealth in negative way ( Black money) ,can make person like a demon .Then he will not get Moksha ,that is Eternal & Long lasting Happiness & Satisfaction.Businessmen, merchants worship their Accounts diary .Actually everybody of us also can review our Life Book on this day .We have to debit anger,jealousy,hatred,greed,bitter moments & must credit positive qualities like Love,Faith,Enthusiasm

3)  Padva ( Bala Pratipada) – New year is called as Balapratipada.King Bali was famous for his generosity & Donations.We must remember these qualities of Bali on this day.God Vishnu believes  that Wealth ( Kanak in Sanskrit) & Woman (Kanta in Sanskrit) ,if not understood properly ,can make person blind in the attraction of Wealth & woman. Person can not then discriminate Good & Bad. So God Vishnu teaches us to look towards Wealth & Woman in a respectful manner ( Laxmi Pujan & Bhau beeja,these 2 days are representing this Theme)

4)  Bhau beej – Bhau means brother. Person should look towards any woman ( Except his wife) as a mother or sister & try to protect her

Deepavali is Festival of Lights .Everybody lights oil lamps ,Lanterns. This is O.K, Good, Fine. But more important is to light the inside lamp. Greed & Ignorance are dark side of our life .Knowledge is a lamp ,which removes our Ego, Greed ,Jealousy & make our life more beautiful & meaningful.

On Narakchaturdashi ,kill our demon like habits of Laziness,Unclinliness,Lust,Selfish,Ego etc.On Laxi pujan we must understand importance of wealth ,acquired in a righteous way ,in our Life.On Balapratipada we have to make Balance sheet of our life Book.On Bahu beej ,we must learn to respect women.

New year is for New ,holy determinations ,forgetting past darkness .If these cultural Teaching could ignite our inner conscious ,then every day in our life will be Deepavali .Am I right ?

 Please write me back on – mailme.drrrdeshpande@rediffmail.com or call me on 922 68 10 630

Kindly note that my personal web site – www.ayurvedicfriend.com is under renewation.Will open within a month or so .Thanks


Happy Diwali to you all !! God bless you !!

Sunday 27 October 2013

Significance of Laboratory Test in Medical Practice on 28-10-13

Subject -- Significance of  Important Pathology Investigations in Medical Practice 

Expert -- Dr.Ratnakar Pathologist  ,
Editor -- Prof .Dr.R.R.Deshpande

This post is very useful for 3rd BAMS Students & Medical General Practitioners

Dear Friends ,please write me back on -- mailme.drrrdeshpande@rediffmail.com or call me on 9226810630 

SR NO
NAME OF THE TEST
INDICATION OF THE TEST
CLINICAL PRESENTATION
HAEMATOLOGY
1
PTTK / APTT
To detect Coagulation abnormalities.
Liver disease / DIC / HAEMOPHILIA / HEPARIN Rx.
2
Sickling Test
To detect Sickle Cell Anemia
Anemia - weakness / pallor/ koilonychias etc
3
Reticulocyte Count
To assess Bone Marrow activity and monitor response.
In response to anaemia therapy
4
Coomb’s Test ( Direct)
To detect auto antibodies against RBCs , that may result from various diseases.
AIHA - Autoimmune Haemolytic anaemia ,
Chronic Lymphoproliferative Disorders - CLL
Drug Induced Haemolysis
HDN - Haemolytic Disease of New Born.
5
Coomb’s Test ( Indirect)
To detect antibodies in unbound state in serum.
6
G6 PD Estimation
To detect G6PD deficiency.
Haemolytic Anemia and the presentation.
7
D-Dimer
Elevated in Thromboembolism and active venous thrombosis.
DVT / DIC / PE
8
HB Electrophoresis
Haemoglobinopathies.
Sickle cell Anemia / Thallassemia
Anemia - weakness / pallor/ koilonychias etc
9
Sr.Ferritin
To study Iron Metabolism disorders.
10
Sr.Iron & TIBC
BIOCHEMISTRY
1
Urine Micro Albumin
done in cases of DM to rule out Diabetic Nephropathy.
Known case of Diabetes.
2
APO A / APO B
To evaluate risk of Atherosclerosis
RECOMMENDED FOR EVERY INDIVIDUAL ABOVE 30 YEARS OF AGE - Blame it on lifestyle.
3
LP ( A)
To evaluate risk of Atherosclerosis
4
Homocysteine
Risk factor for CHD , Vitamin B deficiency , disorders of metheonine metabolism
ELEVATED LEVELS ARE SEEN IN - VIT B12 def. , CRF / CHD / Hypothyroidism
Low levels are seen in Down's / Pregnancy.
5
Blood Urea Nitrogen / Creatinine
done in cases of Kidney diseases , GI bleed , cancer patients
Signs and symptoms of Renal insufficiency / differentiation of prerenal / renal / post renal azotemia.
6
Acid Phosphatase with Prostatic Fraction
Prostatic Diseases , Storage disorders - Gaucher's / Niemann Pick's , Vaginal swabs of rape victims.
Known cases of Ca Prostate
7
GGTP
ELEVATED in liver disease
Screening test for Alcoholism , Various Liver patholgies , Pancreatitis , DM , RA , COPD , Tumours
8
CPK (Total)
Necrosis , Muscular disorders
Muscular dystrophies
9
CK--MB
Marker for MI , recent MI , rhabdomyolysis , muscular dystrophy
Cardiac markers - Chest pain , Myocarditis
10
Phosphorus
Renal diseases
Acute / Chronic renal failure
11
Ammonia
Renal diseases
Acute / Chronic renal failure
12
Magnesium
Renal diseases
Acute / Chronic renal failure




1
IgE
ALLERGY
Important marker of allergy
SEROLOGY
Sr,No.
Test
Indication

1
CRP
Marker of inflammation
Ischemia , Tissue injury or necrosis , Malignancy or post surgery
2
Hs - CRP
More sensitive marker for Inflammation
3
LE cell Phenomenon
To detect SLE.
Crude test - Obsolete nowadays
4
ANA
Connective Tissue Disorders , SLE , RA …
Rheumatic Diseases
5
Anti DS DNA
Specific test for SLE.
Advanced stages of SLE clinically
6
P – ANCA/C- ANCA
Vasculitis , WG , CSS , Connective Tissue Disorders
Vasculitis , Ulcerative Colitis , Crohn's Disease
7
HLA B - 27
Ankylosing spondylitis , Reiter's syndrome
HLA - CROSS MATCH - DONE IN EXCEPTIONAL CASES
8
Protein Electrophoresis


9
Anti CCP Antibody
Rheumatoid Arthritis
Differentiation of RA with other arthritis
10
ANA Blot
Connective Tissue Disorders , SLE , RA …
symptoms related to systems involved .
11
HIV PCR (Qualitative)


12
HBV PCR (Quantitative)


13
HBV PCR (Qualitative)


14
Alfa Feto Protein
Marker of various cancers - Hepatic / Germ cell
Used in cases of known cancers - to detect recurrence
15
B - hCG
Pregnancy / Ectopic / Gestational Tropho Disease
Imp is Threatened abortions
16
PSA
Prostate cancer screening and Follow ups
monitoring of patients
17
Torch IgG & IgM
TOXOPLASMA , RUBELLA , CYTOMEGALOVIRUS , HEPATITIS
IgM - RECENT INF / IgG - CHRONIC
TESTS TO BE ORDERED IN CASES OF BAD OBSTETRIC HISTORY
18
Torch IgM only
19
CMV – IgG & IgM
20
Anti Cardiolipin IgG,IgM.IgA
ANTIPHOSPHOLIPID SYNDROME
CLINICAL AND LAB CRITERIA ARE THERE FOR FINAL DIAGNOSIS
SEEN IN CASES OF SLE , CANCERS , ACUTE INFECTIONS DRUG EFFECTS
21
Anti Phospholipids Antibody
22
Lupus Anti coagulant




Sr,No.
Test
Indication

1
Free T3
THYROID DISORDERS
Hyper and Hypo thyroidism
2
Free T4
3
TSH (Ultrasensitive)
4
FSH
Hyper / Hypo gonadism , Precautious puberty
Cases of Infertility  , Amenorrhoea , Bad obstetric History , Ectopic Hormone production , CRF , Liver failure , Drug effects ,
5
LH
6
Prolactin
prolactine secreting tumours
7
B - HCG
Pregnancy / Ectopic / Gestational Tropho Disease
Imp is Threatened abortions
8
Progesterone
Detection of Ovulation , Pregnancy , tumours
Imp is Threatened abortions , Toxaemias , Gonadal agenesis
9
Testosterone
To evaluate Hormonal / Functional status
Virilising tumours / Hirutism / Hypo / Klinefelter's/ Estrogens therapy
10
Estradiol(E2)
Hyper / Hypo - Gynecomastia , Estrogens producing tumours
Feminization in children , Hepatic Cirrhosis
11
Growth Hormone
Hyper / Hypo pituitarism
Acromegaly / Chronic diseases
12
Cortisol AM/PM
Adrenal insufficiency
HYPER AND HYPO disorders
13
Dhea – SO4
Adrenal insufficiency , Cushing's syndrome
increased in Cushing's / Cancers / PCOD ,
decreased in Addison's
14
Estriol ( E3)
PREGNANCY ESTROGENS

15
C Peptide
Levels directly proportional to Insulin levels as both are coreleased in blood
Increased in Insulinoma / Type 2 DM.
Decreased in Type 1 and Exogenous Insulin Admin.
16
Insulin F/PP
done along with Glucose levels in cases of fasting Hypoglycaemia , Insulinomas
Have lot of limitations and is of limited use.
17
Pappa –(1st Trimester)
Pregnancy Associated Plasma Protein A
Low levels are associated with Aneuploidy
18
Triple Test (2nd Trimester)
DONE IN 2ND TRIMESTER PREG - ASSAY INCLUDE AFP, bHCG,Unconj. Estriol
assay gives three values that are determined to assess the risk of Down's Synd , Edward's Synd , Neural Tube defect




Sr,No.
Test
Indication

1
TB – IgG/IgM / IgA
Detection of Unknown Tuberculosis
Various presentations of Tuberculosis - Not diagnostic or suspicious but not confirmed by routine modalities.
2
TB PCR ( Qualitative)
Detection of Unknown Tuberculosis




Sr,No.
Test
Indication

1
VMA
Metabolite of catecholamines done in cases of Pheochromocytoma , Neuroblastoma , Paraganglioma
The test is replaced by fractionated plasma free metanephrines
2
Proteins
Done in cases of Major illnesses - Liver / Kidney / Debilitating disorders
Important marker of Nutritional state of the person.
3
Calcium
Monitoring of various disorders - Bone , Kidney , Parathyroid , GIT
Commonest deficiency in today's era , silent most of the time
4
Creatinine
Renal function assessment

5
Creatinine Clearance
Evaluation of Glomerular Function
Renal disorders , Anemia , Leukemias , Monitoring of renal diseases
6
Sodium
Together considered as electrolytes
Potassium derrangement happens in some cardiac cases too and plenty of other disorders
water electrolyte imbalance , Dehydreations , elevated in Hyperaldosteronism
7
Potassium
8
Uric Acid
Renal function assessment , Gout ,
Monitoring of Gout and Chemoterapeutic agents